Dinner SC 3: Tuesday March 10, 6:00pm – 9:00 pm
Glycobiology of Antibodies
Instructor:
T. Shantha Raju, Ph.D., Scientific Director, Biologics Research, Janssen Research & Development, LLC
Agenda outline:
- Introduction to Protein Glycosylation
- Fc Glycan Heterogeneity
- Methods to Analyze Fc Glycans
- Glycoengineering Methods
- Role of Fc Glycans on Antibody Effector Functions
- Impact of Fc Glycans on Antibody Stability
- Discussion with Q&A
- End of Short Course
Instructor Biography
T. Shantha Raju, Ph.D., Scientific Director, Biologics Research, Janssen Research & Development, LLC
Dr. T. Shantha Raju (Raju) is currently working as a Scientific Director at Janssen R&D of Janssen Pharmaceutical Companies of JNJ. Dr. Raju joined Centocor Inc in 2004 which became Janssen R&D in 2011. At Centocor Dr. Raju has worked as an Assistant Director and then as a Research Fellow. Prior to Centocor, Dr. Raju has spent more than 5 years at Genentech and then sometime at Fibrogen and Prozyme. Dr. Raju’s research interest is to explore structure-functional relationship of antibody glycosylation and glycoprotein therapeutics. Dr. Raju has more than 17 years of experience in the research and development of biotherapeutics including monoclonal antibodies and glycoproteins. Dr. Raju was involved in the development of leading cancer therapeutics such as Rituxan, Herceptin, Avastin and immunology therapeutics such as Remicade, Simponi etc. Dr. Raju has published more than 35 research articles, several reviews and book chapters. He is currently in the editorial board of mAbs, Analytical Biochemistry, BioProcess International and Drug Discovery and Development journals. Dr. Raju has been a member of ACS and Division of Carbohydrate member for the last 18 years. He is also a member of ASBMB for the past 15 years.